"The dreams are wild and vivid. 16, no. PCOS (polycystic ovary syndrome) and diabetes. While dreams can include visions of grandeur and bliss, they can also be scary, threatening, or stressful. So, if youre taking metformin and experience memory loss as a side effect, it could be your diabetes (and not the medication) thats causing it. WebAlthough metformin is an effective diabetes treatment, it has quite a few potential side effects. Both his global PSQI score and HAM-D17 were 0, and A1C hemoglobin level was 6.7% on the last visit. Many of the warning signs are similar to some metformin side effects, like stomach pain, dizziness, and weakness. 2005 - 2023 WebMD LLC, an Internet Brands company. a component of the emotional response to fear and trauma Some "combination" pills have metformin with another medicine, including: Like any medicine, metformin can have side effects. sharing sensitive information, make sure youre on a federal Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 6(4), 389401. In the present retrospective study, metformin usage in advanced chronic kidney disease (CKD) patients, especially those with CKD 3B, decreased the risk of all-cause mortality and incident ESRD. mental and physical wellness is Its unclear. Nightmares. Additionally, 6, pp. 3039, 2017. daily life? Long term treatment with metformin in patients with Type 2 diabetes and risk of vitamin B-12 deficiency: Randomised placebo controlled trial. WebCommon Side Effects of Metformin Stomach trouble is the most common metformin side effect. Knowing the differences between bad dreams, nightmares, and nightmare disorder is a first step to addressing the causes of nightmares, starting appropriate treatment, and getting better sleep. Nightmares are vivid dreams that may be threatening, upsetting, bizarre, or otherwise bothersome. Medline Plus National Institute of Diabetes and Digestive and Kidney Diseases. Once your doctor is able to rehydrate you and lower your blood sugar, the hallucinations will end. Elhadd, T., et al. Metformin, according to some reports, can cause insomnia, as well as other sleep issues. He reported his dream as an unpleasant experience which awakened him at night with negative feelings. Current Diabetes Reports. 2022 Sep 9;14(9):e28974. Select one or more newsletters to continue. Centers for Disease Control and Prevention. For that reason, it is important to talk with a doctor who can describe the potential benefits and downsides of prescription drugs for nightmare disorder. Written informed consent was obtained from the patient for publication of this case report. Also I have found that it's important to have good calories for your body to burn. Nightmare disorder, though, is far less common. 1, pp. REM sleep Intense dreams aren't a problem compared to the struggle of living with anxiety. Let your health care team know that you take metformin before you have an imaging test, Diabetologia: Metformin: historical overview, Metformin and the gastrointestinal tract, Metformin for diabetes prevention: insights gained from the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study., Diabetes Care: Standards of Medical Care in Diabetes2019, Long-Term Safety, Tolerability, and Weight Loss Associated With Metformin in the Diabetes Prevention Program Outcomes Study., Cell Reports: Hyperglucagonemia mitigates the effect of metformin on glucose production in prediabetes.. Trusted Source Even though it is the most plausible cause in this case, there are some theoretical issues worthy of mentioning. The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. All authors read and approved the final manuscript. The medication can interfere with the absorption of vitamin B12, a vitamin you need to maintain healthy blood cells. 277287, 2010. Orv Hetil. This is a dangerous condition caused by the buildup of lactic acid, a chemical that your muscles and red blood cells make naturally. Research studies estimate that about 2%-8% of adults have problems with nightmares. Case presentation: (2007). (2011). Our editors and medical experts rigorously evaluate every article and guide to ensure the information is factual, up-to-date, and free of bias. Moreover, sleep disorder and disordered dreaming were commonly found in patients with T2DM with overall prevalence as high as 50% [6]. 2, pp. Theo Audi Yanto and Nata Pratama Hardjo Lugito supervised and gave expert advice regarding the manuscript. H. Denic-Roberts, T. Costacou, and T. J. Orchard, Subjective sleep disturbances and glycemic control in adults with long-standing type 1 diabetes: The Pittsburgh's Epidemiology of Diabetes Complications study, Diabetes Research and Clinical Practice, vol. It helps bring down your blood sugar level in three ways: It can lower your A1c, the "average" of your blood sugar control over a few months. If you're ready for more, sign up to receive our email newsletter! Metformin has been shown to lower the risk of cardiovascular events like heart attacks and help lower the risk of Type 2 diabetes complications like poor vision, impaired kidney function, and chronic nerve pain. The dreams were vivid and indescribable. This is true for any product with high levels of NDMA, not just metformin. Sleep Medicine Clinics. -, Philpott H. L., Nandurkar S., Lubel J., Gibson P. R. Drug-induced gastrointestinal disorders. Despite the fact that the precise pathophysiology of disordered dreaming is largely unknown and possibly involves complex neurochemical process, drugs that affected neurotransmitters and rapid eye movement (REM) sleep have been shown to cause nightmares [5]. Metformin is widely known as an antidiabetic agent which has significant gastrointestinal side effects, but nightmares and abnormal dreams as its adverse reactions are not well reported. The disappearance and occurrence of abnormal dreams ensued soon after the drug was discontinued and rechallenged. National Library of Medicine, Biotech Information I do intend to speak to my dr about it but I was wondering if this is a temporary side effect while my body is adjusting to the medication or if its something I should be concerned about. Trusted Source Current Pharmaceutical Design. This can lead to chronic nerve pain. To do that, keep track of your blood sugar and follow your doctor's recommendations for treatment and a healthy lifestyle. The nightmare only lasted for a night, but his dreams every night thereafter seemed abnormal. HHS Vulnerability Disclosure, Help American Federation for Aging Research. 243247, 2014. That can affect the communication between your brain cells and lead to hallucinations. (2018). National Library of Medicine, Biotech Information Studies are needed to confirm the association and causality of these findings. More studies are needed to confirm the association and causality Davis, J. L., Rhudy, J. L., Pruiksma, K. E., Byrd, P., Williams, A. E., McCabe, K. M., & Bartley, E. J. Case Rep Endocrinol. National Library of Medicine, Biotech Information This often leads to further sleep avoidance, giving rise to a pattern of disturbed sleep that culminates in insomnia. 164, no. Metformin is a leading cause of nightmares in users. It doesn't effect our brain. Along with checking your sugar levels regularly, you should be aware of the signs that it may be running high. The dreams were vivid and indescribable. PCOS can cause insulin resistance, which can lead to high blood sugar levels. eCollection 2021. Building better sleep habits is a component of many therapies for nightmare disorder and can pave the way for high-quality sleep on a regular basis. S. Wiwanitkit and V. Wiwanitkit, Metformin and sleep disorders, Indian Journal of Endocrinology and Metabolism, vol. no consensus explanation for why we have nightmares Disturbed dreaming and the instability of sleep: altered nonrapid eye movement sleep microstructure in individuals with frequent nightmares as revealed by the cyclic alternating pattern. and consolidating memory. Read our editorial policy. -, Gionfriddo M. R., Morey-Vargas O. L., Brito J. P., Leppin A. L., Murad M. H., Montori V. M. Systematic reviews to ascertain the safety of diabetes medications topical collection on pharmacologic treatment of type 2 diabetes. Feb 21, 2011. Trusted Source According to Dr Mark Silvert, consultant psychiatrist and medical director at The Blue Tree Clinic, the increased amount of neurotransmitters in the brain may be linked to changes to how we dream. All rights reserved. Annals of Translational Medicine. Your blood work should be monitored by your healthcare provider to make sure that youre not seeing a significant drop in vitamin B12. (2002). Elsevier (2010). 119, pp. Early effects of metformin in women with polycystic ovary syndrome: A prospective randomized, double-blind, placebo-controlled trial. or fin Video appointments with qualified counsellors are now available in Patient Access. Exposure, Relaxation, and Rescripting Therapy (ERRT), Best Anti-Snoring Mouthpieces & Mouthguards, Regular Distressing Dreams in Childhood Tied to Higher Risk of Cognitive Impairment, Discussing Dreams Thought to Help People Cope During the COVID-19 Pandemic, Low Level of Lucid and COVID-19-Specific Dreams Found During the Pandemic, Recommendations Given to Support End-of-Life Dreams and Visions, https://pubmed.ncbi.nlm.nih.gov/26401306/, https://pubmed.ncbi.nlm.nih.gov/10779247/, https://linkinghub.elsevier.com/retrieve/pii/S1087079210000638, http://doi.apa.org/getdoi.cfm?doi=10.1037/0033-2909.133.3.482, https://www.ninds.nih.gov/Disorders/All-Disorders/Hypersomnia-Information-Page, https://pubmed.ncbi.nlm.nih.gov/32268482/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958868/, https://pubmed.ncbi.nlm.nih.gov/23449753/, https://pubmed.ncbi.nlm.nih.gov/30697860/, https://jcsm.aasm.org/doi/full/10.5664/jcsm.27883, https://medlineplus.gov/ency/article/003209.htm, http://article.psychiatrist.com/?ContentType=START&ID=10001541, https://pubmed.ncbi.nlm.nih.gov/22171201/, The Relationship Between Depression and Sleep. 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